A. Laboratory introduction
Beijing university medical health isotope analysis laboratory was established in 2001, the main research direction for the diagnosis and treatment of radioactive drug research and development, radiation receptors analysis, radiation immune analysis and radioactive tracer technology application in biology, mainly responsible for WangFan professor. At present the lab has built a from molecular level, a cellular level to the organization and living imaging of radioactive level molecular probes of the preparation and evaluation technology platform, and using that technology platform bear and completed a number of national and provincial scientific research projects, including national science research project, the "863" project, the national natural science foundation of China, Beijing science and technology plan projects and the ministry of education "985" and "211" project.
Second, laboratory testing project
? antibody (peptide) metal nuclide (99 mTc, 111 In, 90 Y and 177 Lu, etc) and nonmetallic nuclide (125 I and 131 I) mark, including direct marker method and the indirect notation. In the indirect labeling include antibody (peptide) and the double function connection agent coupling and purification.
? established the radioactive molecular probes of the quality control method and purification methods.
? at the molecular and cellular level appraisal corresponding antigen (receptor) of expression, and the determination of antibody (peptide) and antigen (receptor) affinity with and specificity.
? tumor tissue to the antigen (receptors) to identify the expression level. Through the disembodied immunohistochemistry analysis, using fluorescence imaging, identify the tumor and other organization of antigen (receptor) expression level.
? by mice determination of the radioactive molecules probes of the body pharmacokinetics.
? evaluation body inside and outside of the radioactive molecular probe stability.
? evaluation radioactive molecular probe in the body LuoShu tumor-burdened biological distribution.
? tumor-burdened on LuoShu gamma imaging.
? determination radioactive molecular probe in mice biggest dose of tolerance (MTD).
? dose for study, evaluation radioactive molecular probe to normal organization and the tumor in the radiation dose.
? through experimental evaluation LuoShu tumor-burdened radioactive molecular probes of the therapeutic effect.
? evaluation radioactive molecular probes of the toxicity.
Three, laboratory personnel
The Lord let: WangFan (doctor)
The researchers: JiaBing, ZhaoHuiYun, AnLiZhi, ShiJiYun